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Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis - دانلود رایگان



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دانلود رایگان Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysisلینک دانلود رایگان مقاله:
http://s8.picofile.com/file/8299383700/DOC_20170622_WA0006.pdf.html




ارتباط بین طول تلومر و دیابت نوع2: متاآنالیز

چکیده:

پیشینه: مطالعات اپیدمیولوژیکی متعدد ارتباط بین طول تلومر کوتاه شده و دیابت نوع 2 یا T2DM را بررسی کرده‌اند، در حالی که نتایج متعارض باقی ماندند. نتیجه گرفتیم که متاآنالیز برآورد دقیق تری را درباره ارتباط بین آن‌ها ارائه می‌دهد.

روش‌ها: به طور منظم پایگاه‌های داده ای pubmed، EMBASE و وب علوم را برای تمام مطالعات درباره ارتباط بین طول تلومر و T2DM بررسی کردیم. به این نتیجه رسیدیم که این مطالعه با استفاده از STATA11.0 ارزیابی شد. داده‌ها با استفاده از اثرات تصادفی یا اثرات ثابت متاآنالیز به طور خلاصه ارائه شدند. ناهمگنی یا ناهماهنگی و تحت تاثیر بودن انتشار مطلوب در میان مطالعات با استفاده از آزمون آماری Q مبتنی بر X2 و آزمون Egger بررسی شدند(به ترتیب).

نتایج: 9 گروه متشکل از 5759 مورد و 6518 کنترلی در متاآنالیز انتخاب شدند. نتایج نشان داد که طول تلومر کوتاه شده به طور قابل توجهی با ریسک T2DM مرتبط و دارای ناهمگنی L2=71/6 می‌باشد(OR=1/291,95%,CL=1/112,1/498,P<0/001). هنگامی که سه گروه مسئول نامتجانسی مستثنی شدند، OR بدست آمده برای گروه‌های باقیمانده ارتباط معنادار بین طول تلومر کوتاه شده و T2DM بدون نامتجانس را نشان داد.
نتیجه گیری: ارتباط معنادار بین طول تلومر کوتاه شده و T2DM را از لحاظ آماری بدست آوردیم.


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فایل فلش


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گزارش تخصصی


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Leukocyte telomere length is associated with …

17/10/2011 · Diabet. Med. 28, 1388–1394 (2011)Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for diabetes complications have been extensively...

Association between Telomere Length and Type 2 …

21/11/2013 · Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.

(PDF) Type 2 diabetes mellitus, physical activity, …

PDF | Background: Type 2 diabetes mellitus (DM), a chronic metabolic disease prevalent in adults, is also prevalent amongst children, adolescents and... | Find, read and cite all the research you ...

Association between Telomere Length and Type 2 Diabetes ...

Background:Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.

Association between telomere length and type 2

Meta-analysis of nine studies consisting of 5759 cases and 6518 controls. Summary In a meta-analysis of 5759 cases and 6518 controls in nine cohorts, shortened telomere length was significantly associated with type two diabetes mellitus (OR: 1.291; P,0.001) with heterogeneity (I2 = 71.6%).

Association between telomere length and diabetes …

Objective We investigated the relationship between diabetes and telomere length by meta-analysis. Methods We searched five popular databases for articles published between 1990 and 2015 using "diabetes" and "telomere" as search terms. Data were processed with RevMan5, and random- or fixed-effects meta-analysis was applied.

Association between telomere length and …

We identified a significant association between telomere length and diabetes mellitus (standardized mean difference [SMD]: −3.41; 95% confidence interval [CI]: −4.01, −2.80; heterogeneity ...

Leucocyte telomere length and risk of type 2

We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies. Methods: Leucocyte relative telomere length (RTL) was measured using quantitative polymerase chain reaction in 684 participants of the prospective population-based Bruneck Study (1995 baseline), with repeat RTL measurements performed in 2005 (n = 558) and 2010 (n ...

(PDF) Telomere length and type 2 diabetes in …

Increased telomere shortening has been demonstrated in several diseases including type 2 diabetes. However, it is not known whether telomere length changes during the course of type 2 diabetes.

Telomere Length and All-Cause Mortality: A Meta

01/12/2018 · Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL) and all-cause mortality remain inconsistent. In the present study, a meta-analysis was performed using published cohort studies and un-published data from the Swedish Twin Registry (STR).

Leukocyte telomere length is associated with …

Med. 28, 1388–1394 (2011) Abstract Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for diabetes complication... Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus - Testa - 2011 - Diabetic Medicine - Wiley Online Library

Leucocyte telomere length and risk of type 2

We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies. Methods: Leucocyte relative telomere length (RTL) was measured using quantitative polymerase chain reaction in 684 participants of the prospective population-based Bruneck Study (1995 baseline), with repeat RTL measurements performed in 2005 (n = 558) and 2010 (n ...

Association between Telomere Length and Type 2 …

21/11/2013 · Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.

Correlation of the telomere length with type 2

01/12/2018 · The telomere shortening is hypothesized as the biomarker for age and age-related diseases. 18 Diabetes, complicated by cardiovascular diseases, increases mortality and results in higher levels of oxidative stress and inflammation, which in turn accelerate the telomere shortening. 11 Similarly, in our study, the telomere length in IHD patients with type 2 DM was significantly low …

Association of telomere length with type 2 diabetes ...

2.1.1. University College London Diabetes and Cardiovascular disease Study (UDACS) The UDACS is a cross-sectional sample of diabetes patients, according to the World Health Organization criteria , designed to study the association between common genetic variants and biochemical risk factors implicated in coronary heart disease (CHD) in patients with diabetes.

Telomere Length and All-Cause Mortality: A Meta

01/12/2018 · Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL) and all-cause mortality remain inconsistent. In the present study, a meta-analysis was performed using published cohort studies and un-published data from the Swedish Twin Registry (STR).

Leucocyte telomere length and risk of type 2

We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies. Methods: Leucocyte relative telomere length (RTL) was measured using quantitative polymerase chain reaction in 684 participants of the prospective population-based Bruneck Study (1995 baseline), with repeat RTL measurements performed in 2005 (n = 558) and 2010 (n ...

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