Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis - دانلود رایگان
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دانلود رایگان Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysisلینک دانلود رایگان مقاله:
http://s8.picofile.com/file/8299383700/DOC_20170622_WA0006.pdf.html
ارتباط بین طول
تلومر و دیابت نوع2: متاآنالیز
چکیده:
پیشینه: مطالعات اپیدمیولوژیکی متعدد ارتباط بین طول تلومر کوتاه
شده و دیابت نوع 2 یا T2DM را بررسی کردهاند، در حالی که نتایج متعارض باقی ماندند. نتیجه
گرفتیم که متاآنالیز برآورد دقیق تری را درباره ارتباط بین آنها ارائه میدهد. روشها: به طور منظم پایگاههای داده ای pubmed، EMBASE و وب علوم را
برای تمام مطالعات درباره ارتباط بین طول تلومر و T2DM بررسی کردیم. به
این نتیجه رسیدیم که این مطالعه با استفاده از STATA11.0 ارزیابی شد. دادهها
با استفاده از اثرات تصادفی یا اثرات ثابت متاآنالیز به طور خلاصه ارائه شدند.
ناهمگنی یا ناهماهنگی و تحت تاثیر بودن انتشار مطلوب در میان مطالعات با استفاده
از آزمون آماری Q مبتنی بر X2 و آزمون Egger بررسی شدند(به ترتیب). نتایج: 9 گروه متشکل از 5759 مورد و 6518 کنترلی در متاآنالیز
انتخاب شدند. نتایج نشان داد که طول تلومر کوتاه شده به طور قابل توجهی با ریسک T2DM مرتبط و دارای
ناهمگنی L2=71/6 میباشد(OR=1/291,95%,CL=1/112,1/498,P<0/001). هنگامی که سه گروه مسئول نامتجانسی مستثنی شدند، OR بدست آمده برای
گروههای باقیمانده ارتباط معنادار بین طول تلومر کوتاه شده و T2DM بدون نامتجانس
را نشان داد.
نتیجه گیری: ارتباط معنادار بین طول تلومر کوتاه شده و T2DM را از لحاظ آماری بدست آوردیم.
Association
between
Telomere
Length
and
Type
2
Diabetes
Mellitus:
A
Meta
Analysis
مقاله
پاورپوینت
فایل فلش
کارآموزی
گزارش تخصصی
اقدام پژوهی
درس پژوهی
جزوه
خلاصه
Association between Telomere Length and Type …
Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis Article (PDF Available) in PLoS ONE 8(11):e79993 · November 2013 with 31 Reads How we measure 'reads'
Leukocyte telomere length is associated with …
Med. 28, 1388–1394 (2011) Abstract Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for diabetes complication... Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus - Testa - 2011 - Diabetic Medicine - Wiley Online Library
Association between telomere length and …
Accordingly, the literature included in the meta-analysis was selected based on the following criteria: 1) it assessed the association between diabetes mellitus and telomere length; 2) it included case-control groups and a complete set of data; 3) the human subjects analyzed included adults only; and 4) it provided standardized mean differences (SMD) and 95% confidence intervals (CIs) or ...
Association between telomere length and …
We identified a significant association between telomere length and diabetes mellitus (standardized mean difference [SMD]: −3.41; 95% confidence interval [CI]: −4.01, −2.80; heterogeneity ...
Association between telomere length and …
Accordingly, the literature included in the meta-analysis was selected based on the following criteria: 1) it assessed the association between diabetes mellitus and telomere length; 2) it included case-control groups and a complete set of data; 3) the human subjects analyzed included adults only; and 4) it provided standardized mean differences (SMD) and 95% confidence intervals (CIs) or ...
Leucocyte Telomere Length and Risk of Type 2 …
12/11/2014 · Background Short telomeres have been linked to various age-related diseases. We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies. Methods Leucocyte relative telomere length (RTL) was measured using quantitative polymerase chain reaction in 684 participants of the prospective population-based …
Correlation of the telomere length with type 2 …
01/12/2018 · The telomere shortening is hypothesized as the biomarker for age and age-related diseases. 18 Diabetes, complicated by cardiovascular diseases, increases mortality and results in higher levels of oxidative stress and inflammation, which in turn accelerate the telomere shortening. 11 Similarly, in our study, the telomere length in IHD patients with type 2 DM was significantly low …
Association between Telomere Length and Type …
Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis
Leukocyte telomere length is associated with …
Med. 28, 1388–1394 (2011) Abstract Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for diabetes complication... Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus - Testa - 2011 - Diabetic Medicine - Wiley Online Library
Association between Telomere Length and Type 2 …
Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a...
Telomere length in atherosclerosis and diabetes
2. Telomere length in diabetes. It is now becoming apparent that type 2 diabetes (T2D) is also characterised by shorter telomeres [10,26,14,15].It is not clear though, from the cross-sectional data available so far, whether the observed shorter telomeres in diabetes …
Association between telomere length and diabetes …
07/11/2016 · Accordingly, the literature included in the meta-analysis was selected based on the following criteria: 1) it assessed the association between diabetes mellitus and telomere length; 2) it included case-control groups and a complete set of data; 3) the human subjects analyzed included adults only; and 4) it provided standardized mean differences (SMD) and 95% confidence intervals (CIs) or presented …
Association between telomere length and type 2 …
21/11/2013 · BACKGROUND: Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.
Association of telomere length with type 2 diabetes ...
2.1.1. University College London Diabetes and Cardiovascular disease Study (UDACS) The UDACS is a cross-sectional sample of diabetes patients, according to the World Health Organization criteria , designed to study the association between common genetic variants and biochemical risk factors implicated in coronary heart disease (CHD) in patients with diabetes.
Association between Telomere Length and Type 2 …
21/11/2013 · Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.
Association between telomere length and diabetes …
07/11/2016 · Accordingly, the literature included in the meta-analysis was selected based on the following criteria: 1) it assessed the association between diabetes mellitus and telomere length; 2) it included case-control groups and a complete set of data; 3) the human subjects analyzed included adults only; and 4) it provided standardized mean differences (SMD) and 95% confidence intervals (CIs) or presented …
Association between Telomere Length and Type 2 …
Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.
Leucocyte Telomere Length and Risk of Type 2 …
12/11/2014 · Background Short telomeres have been linked to various age-related diseases. We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies. Methods Leucocyte relative telomere length (RTL) was measured using quantitative polymerase chain reaction in 684 participants of the prospective population-based …
Association between telomere length and …
Seventeen articles were obtained from 571 references. We identified a significant association between telomere length and diabetes mellitus (standardized mean difference [SMD]: −3.41; 95% confidence interval [CI]: −4.01, −2.80; heterogeneity, I 2 = 99%) by comparing 5575 patients with diabetes and 6349 healthy individuals. The pooled SMD by geographic region indicated a significant ...
Leukocyte telomere length is associated with …
17/10/2011 · Diabet. Med. 28, 1388–1394 (2011)Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for diabetes complications have been extensively...
Association between Telomere Length and Type 2 …
21/11/2013 · Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them.